News 

Jan 11 A collaboration with Prof. Madsens group was accepted for publication in Organic & Biomolecular Chemistry.

2011

Dec 22 A collaboration with Prof. Riisagers group was tentatively accepted for publication in Chemical Communications.

Dec 1 We welcome Esben Fisker as new PhD student.

Aug 22 Peter is awarded the Sapere Aude Research Leader Award. The project concerns biomass utilization and is described under research interests. February 15 Peter B. Jensen defends his M.Sc. thesis and receives a nice 12 (=A). As opponent we were happy to host Prof. Jan H. Jensen from Copenhagen University. January 4.  Peter B. Jensen hands in his M.Sc. thesis on modelling subtilisin using a reactive force-field (ReaxFF).   2010   November 30. Dr. Winifred Odozi joins the group as a visiting PostDoc. November 24. Paper on the mechanism for a Palladium-catalyzed allylic alkylation accepted for publication in Chemistry - A European Journal. November 11. Paper on the structure and mechanism behind development of resistance to a novel treatment of cancer was accepted for publication in BMC Cancer.  August 31.  A paper on the mechanism for dehydration of glucose to HMF accepted for publication in Chemistry - A European Journal. March 15 Casper Junker Engelin joins the group as a PhD student Januar 15 Peter B. Jensen joins the group as a MSc student.   2009    December 1 Ilya Makarov joins the group as a PhD student on a project carried out in collaboration with Prof. Robert Madsen. October 7 Xenia Juel Fristrup turns 1 year! October 1 Alessandro Corozzi joins the group as a PhD student. September 1 Sergio Rodriguez joins the group as PostDoc. July 23 Elucidation of substrate preference (thio-ester vs. oxygen-ester) of the sPLA2 enzyme is accepted for publication in JACS. June 8 2009 Two PhD positions are available, more info here. May 26 2009 Peter moves to DTU and establishes an independent reserach group. May 4 A collaboration with Prof. Poli in Paris on Pd-catalyzed allylic alkylation is accepted for publication in Synlett. Mar 1 2009 Peter assumes a position as assistant professor at KU Farma. Jan 29 2009 Peter was awarded "Ung Eliteforsker pris" (Young Elite Research) by danish minister of Science Helge Sander. General information on the award (www.eliteforsk.dk) and details on my research project here.   2008   Oct 7 2008 Xenia Juel Fristrup is born! Jun 2008 Peter was awarded a three-year research grant from The Danish Research Council for Technology and Production Science (FTP) Mar 2008 Peter was awarded additional funding from the Lundbeck Foundation   2007   Dec 2007 Peter was awarded a PostDoc stipend from the Carlsberg Foundation

Collaborations

National Collaborations

Robert Madsen, Technical University of Denmark          
Mads Clausen, Technical University of Denmark

Thomas E. Nielsen, Technical University of Denmark

Günther Peters, Technical University of Denmark         

Thomas Ruhland, Lundbeck A/S

Allan Svendsen, Novozymes A/S

International Collaborations      

William A. Goddard, III (Caltech, USA)

Adri C. T. van Duin (Penn State University, USA)

Giovanni Poli (Paris VI, France)

Per-Ola Norrby (University of Gothenburg, Sweden

Kenneth Wärnmark (Lund University, Sweden) 
 

Publications As of January 2012 (ISI): 30 publications, 450 citations, Averages Citations per Article: 15 and H-index 13. ResearcherID: A-7211-2008    30. Peter Fristrup,* Matyas Tursky and Robert Madsen "Mechanistic investigation of the iridium-catalysed alkylation of amines with alcohols", Org. Biomol. Chem. 2012, 10, 2569-2577.   29. Søren Kegnæs, Jerrik Mielby, Uffe V. Mentzel, Thomas Jensen, Peter Fristrup, and Anders Riisager* "One-pot Synthesis of Amides by Aerobic Oxidative Coupling of Alcohols or Aldehydes with Amines using Supported Gold and Base as Catalysts", Chem. Comm., 2012, 48, 2427-2429.   28. Kim, S.-K., P. Fristrup, R. Abrol, W. A. Goddard, III “Structure-Based Prediction of Subtype Selectivity of Histamine H3 Receptor Selective Antagonists in Clinical Trials” J. Chem. Inf. Model. 2011, 51 (12), 3262–3274.   27. Casper Junker Engelin, Peter Fristrup, "Palladium Catalyzed Allylic C-H Alkylation: A Mechanistic Perspective", Molecules 2011, 16, 951-969.   26. Xavier Bantreil, Guillaume Prestat, Aitor Moreno, David Madec, Peter Fristrup, Per-Ola Norrby, Paul S. Pregosin, Giovanni Poli, "γ- and δ-Lactams via Palladium-Catalyzed Intramolecular Allylic Alkylation: Enantioselective Synthesis, NMR Investigations, and DFT Rationalization", Chem. Eur. J. 2011, 17, 2885 – 2896.   25. Uffe Høgh Olesen, Jakob Gramstrup Petersen, Antje Garten, Wieland Kiess, Jun Yoshino, Shin-Ichiro Imai, Mette Knak Christensen, Peter Fristrup, Annemette Thougaard, Fredrik Björkling, Peter Buhl Jensen, Søren Jensby Nielsen, Maxwell Sehested, "Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase", BMC Cancer 2011, 10:677.   24. Tim Ståhlberg, Sergio Rodriguez-Rodriguez, Peter Fristrup, Anders Riisager, "Metal-Free Dehydration of Glucose to 5-(hydroxymethyl)furfural in Ionic Liquids with Boric Acid as Promoter", Chem. Eur. J. 2011, 17, 1456-1464.   23. Thomas Jensen, Peter Fristrup, "Toward Efficient Palladium-Catalyzed Allylic C-H Alkylation" Chem. Eur. J. 2009, 38, 9632-9640.    22. Lars Linderoth, Peter Fristrup, Martin Hansen, Robert Madsen, Thomas L. Andresen, Günther H. Peters, "Mechanistic study of the sPLA2 mediated hydrolysis of a thio-ester pro anticancer ether lipid" J. Am. Chem. Soc. 2009, 131, 12193-12200.   21. Xavier Bantreil, Guillaume Prestat, David Madec, Peter Fristrup, Giovanni Poli, "Enantioselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Asymmetric Allylic Alkylation" Synlett 2009, 9, 1441-1444.   20. Peter Fristrup, Mårten Ahlquist, David Tanner, Per-Ola Norrby, "On the Nature of the Intermediates and the Role of Chloride Ions in Pd-Catalyzed Allylic Alkylations: Added Insight from Density Functional Theory" J. Phys. Chem. A. 2008, 112, 12862-12867.   19. Ilaria Ambrogio, Giancarlo Fabrizi, Sandro Cacchi, Signe Teuber Henriksen, Peter Fristrup, David Tanner, Per-Ola Norrby, "Unusual selectivity-determining factors in the phosphine-free Heck arylation of allyl ethers" Organometallics 2008, 27, 3187-3195.   18. Peter Fristrup, Louise Bahn Johansen, Claus Hviid Christensen, "Mechanistic Investigation of the Gold-Catalyzed Aerobic Oxidation of Aldehydes: Hammett Studies and Isotopic Labelling Experiments" Chem. Commun. 2008, 2750-2752. Cover Illustration on no. 24, June 28, 2008.   17. Johan Hygum Dam, Peter Fristrup, Robert Madsen, "A Combined Experimental and Theoretical Mechanistic Investigation of the Barbier Allylation in Aqueous Media" J. Org. Chem. 2008, 73, 3228-3235.    16. Peter Fristrup, Michael Kreis, Anders Palmelund, Per-Ola Norrby, Robert Madsen, "The Mechanism for the Rhodium-Catalyzed Decarbonylation of Aldehydes: A Combined Experimental and Theoretical Study" J. Am. Chem. Soc. 2008, 130, 5206-5215.   15. Christian Rank, Richard K. Phipps, Jens C. Frisvad, Pernille Harris, Peter Fristrup, Thomas O. Larsen, Charlotte H. Godtfredsen, "Novofumigatonin, a Novel Metabolite from Aspergillus novofumigatus" Org. Lett. 2008, 10, 401-404.   14. Peter Fristrup, Louise Bahn Johansen, Claus Hviid Christensen, "Mechanistic Investigation of the Gold-Catalyzed Aerobic Oxidation of Alcohols" Catal. Lett. 2008, 140, 184-190.   13. Peter Fristrup, Peter R. Lassen, David Tanner, K. J. Jalkanen, "Direct determination of absolute configuration: a vibrational circular dichroism study on dimethyl-substituted phenyloxiranes synthesized by Shi epoxidation" Theor. Chem. Acc. 2008, 119, 133-142.   12. Nina Svensen, Peter Fristrup, David Tanner, and Per-Ola Norrby, "Memory Effects in Palladium-Catalyzed Allylic Alkylations of 2-Cyclohexen-1-yl Acetate" Adv. Synth. Catal. 2007, 349, 459-473.   11. Johannes Due-Hansen, Soghomon Boghosian, Arkady Kustov, Peter Fristrup, George Tsilomelekis, Kenny Ståhl, Claus Hviid Christensen, Rasmus Fehrman, "Vanadia-based SCR Catalysts Supported on Tungstated and Sulfated Zirconia: Influence of Doping with Potassium" J. Catal. 2007, 251, 459-473.   10. Peter Fristrup, Peter R. Lassen, Christian Johannessen, David Tanner, Per-Ola Norrby, Karl. J. Jalkanen, and Lars Hemmingsen, "Direct Determination of Absolute Configuration of Methyl-Substituted Phenyloxiranes: A Combined Experimental and Theoretical Approach" J. Phys. Chem. A 2006, 110, 9123-9129.   9. Peter Fristrup, Thomas Jensen, Jakob Hoppe, and Per-Ola Norrby, "Deconvoluting the memory effect in Pd-catalyzed allylic alkylation; effect of leaving group and added chloride" Chem. Eur. J. 2006, 12, 5352-5360.   8. Mårten Ahlquist, Peter Fristrup, David Tanner, and Per-Ola Norrby, "Theoretical evidence for low-ligated palladium(0): [Pd-L] as the active species in oxidative addition reactions." Organometallics 2006, 25, 2066-2073.   7. Peter Fristrup, Gitte Holm Jensen, Marie Louise Nygaard Andersen, David Tanner, and Per-Ola Norrby, "Combining Q2MM Modeling and Kinetic Studies for Refinement of the Osmium-catalyzed Asymmetric Dihydroxylation (AD) Mnemonic" J. Organomet. Chem.2006, 691, 2182-2198.   6. Lise Keinicke, Peter Fristrup, Per-Ola Norrby, and Robert Madsen, "A Nonradical Zinc-Barbier Reaction for Diastereoselective Synthesisof Vicinal Amino Alcohols" J. Am. Chem. Soc. 2005, 127, 15756-15761.   5. Peter Fristrup, Brian B. Dideriksen, David Tanner, and Per-Ola Norrby, "Probing Competitive Enantioselective Pathways Operating in the Jacobsen-Katsuki Epoxidation: A Kinetic Study of Methyl-substituted Styrenes" J. Am. Chem. Soc. 2005, 127, 13672-13679.   4. David Madec, Guillaume Prestat, Elisabetta Martini, Peter Fristrup, Giovanni Poli, and Per-Ola Norrby, "Surprisingly Mild Enolate Counterion-Free Pd(0)-Catalyzed Intramolecular Allylic Alkylations" Org. Lett. 2005, 7, 995-998.   3. Peter Fristrup, Sebastian Le Quement, David Tanner and Per-Ola Norrby, "Reactivity and Regioselectivity in the Heck Reaction - A HammettStudy of 4-Substituted Styrenes" Organometallics 2004, 23, 6160-6165.   2. Peter Fristrup, David Tanner and Per-Ola Norrby, "Updating the asymmetric osmium-catalyzed dihydroxylation (AD) mnemonic. Q2MM modeling and new kinetic measurements"Chirality 2003, 15, 360-368.   1. Peter Fristrup, Mikala Grubb, Jing-Dong Zhang, Hans Erik Mølager Christensen, Anne Mette Hansen and Jens Ulstrup, "Voltammetry of native and ecombinant Pseudomonas aeruginosa azurin on polycrystalline Au- and single-crystal Au(111)-surfaces modified by decanethiol monolayers" J. Electroanal. Chem. 2001, 511 (1-2), 128-133.     Book chapters and other publications    1.  M. L. D. Thomsen, H. Falsig, P. Fristrup ”Computerkemi – en opdagelsesrejse in silico” in ”Nye Kemiske Horisonter” (eds. C. H. Christensen, C. B. Hansen, M. M. Andersen, L. Linderoth), Technical University of Denmark, Lyngby 2007, p 74 - 87. The book was published by the Department of Chemistry, Technical University of Denmark and distributed to all high schools in Denmark.   2. Peter Fristrup, Signe Teuber Henriksen, Thomas Jensen "Nye tider, nye skikke - kemiske reaktioners effektivitet" Dansk Kemi, 2008, 89, nr. 12, 27-29.   3. Thomas Jensen, Peter Fristrup "Den palladiumkatalyserede Heck-reaktion" Dansk Kemi, 2009, 90, nr. 1, 30-33   4. Thomas Jensen, Peter Fristrup "Den palladiumkatalyserede allyliske alkylering (Tsuji- Trost reaktionen)" Dansk Kemi, 2009, 90, nr. 2., 32-34.   5. Peter Fristrup, Thomas Jensen "Den palladiumkatalyserede arylaminering (Buchwald- Hartwig reaktionen)" Dansk Kemi, 2009, 90, nr. 3., 21-24.   6. Peter B. Jensen, Peter Fristrup ”Reaktive kraftfelter – en genvej til realistiske simuleringer af kemiske reaktioner?” Dansk Kemi, 2011, 92, nr. 12, 27-29.

Curriculum vitae   Education Mar 2003 - Feb 2006 Ph.D Chemistry, Technical University of Denmark, Lyngby, Denmark (www.kemi.dtu.dk) Sep 1997 - Feb 2003 M.Sc. (Chem. Eng.), "Cand. Polyt", Technical University of Denmark, Lyngby, Denmark   Employments Feb 2012 - present   Associate Professor, Department of Chemistry (www.kemi.dtu.dk), Technical University of Denmark (www.dtu.dk) May 2009 - Jan 2012 Assistant Professor, Department of Chemistry, Technical University of Denmark Mar 2009 - Apr 2009 Assistant Professor, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark (www.farma.ku.dk) Mar 2008 - Feb 2009 Post. Doc. Materials and Process Simulation Center, California Institute of Technology, Pasadena, Los Angeles, USA (www.caltech.edu) Mar 2006 - Feb 2008 Post. Doc. Center for Sustainable and Green Chemistry, Technical University of Denmark, Lyngby, Denmark (www.csg.dtu.dk)   Fellowships & Funding 2012 Sapare Aude Research Leader Fellowship from the Danish Council for Independent Research 2009 3-year research grant from the The Danish Research Council for Technology and Production Science (FTP) 2008 Postdoctoral fellowship granted by the Lundbeck Foundation 2008 Postdoctoral fellowship granted by the Carlsberg Foundation   Awards 2012 Sapare Aude Research Leader Award 2009 Young Elite Researcher Award (includes additional funding: DKr. 200.000) 2006 IUPAC poster prize at the Annual Meeting of the Danish Chemical Society  2006 Best PhD Research Work, Technical University of Denmark