Publications (Peer-reviewed articles)     2013     39. J. S. Laursen, J. Engel-Andreasen, P. Fristrup, P. Harris, C. A. Olsen.* Cis–Trans Amide Bond Rotamers in eta-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains. J. Am. Chem. Soc. 2013, 135, 2835-2844.   2012     38. A. S. Madsen, C. A. Olsen.* Profiling of Substrates for the Zinc-Dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro. Angew. Chem. Int. Ed. 2012, 51, 9083–9087.   37. A. S. Madsen, C. A. Olsen.* Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme. J. Med. Chem. 2012, 55, 5582–5590.   36. C. A. Olsen, A. Montero, L. J. Leman, M. R. Ghadiri. Macrocyclic Peptoid–Peptide Hybrids as Inhibitors of Class I Histone Deacetylases. ACS Med. Chem. Lett. 2012, 3, 749–753. (Top twenty downloaded Letter in August 2012).   35. C. J. Vickers, C. A. Olsen, L. J. Leman, M. R. Ghadiri. Discovery of HDAC Inhibitors that Lack an Active Site Zn2+-Binding Functional Group. ACS Med. Chem. Lett. 2012, 3, 505–508. (Top five downloaded Letter in May and June 2012, chosen for the cover art of the April 2013 issue).   34. A. N. Hansen, C. D. Bendiksen, L. Sylvest, T. Friis, D. Staerk, F. S. Jørgensen, C. A. Olsen,* G. Houen.* Synthesis and Antiangiogenic Activity of N-alkylated Levamisole Derivatives. PLoS ONE, 2012, 7(9), e45405.   33. C. A. Olsen.* Expansion of the Lysine Acylation Landscape. Angew. Chem. Int. Ed. 2012, 51, 3755–3756. (Highlight).      2011     32. C. A. Olsen, A. S. Kristensen, K. Strømgaard. Small Molecules from Spiders Used as Chemical Probes. Angew. Chem. Int. Ed. 2011, 50, 11296–11311.    31. D. A. Hutt, C. A. Olsen, C. J. Vickers, D. Herman, M. Chalfant, A. Montero, L. J. Leman, R. Burkle, B. E. Maryanoff, W. E. Balch, M. R. Ghadiri. Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of DF508-CFTR. ACS Med. Chem. Lett. 2011, 2, 703–707.   30. C. A. Olsen, beta-Peptoid “Foldamers” – Why the Additional Methylene Unit? Biopolymers (Pept. Sci.) 2011, 96, 561–566.       Postdoctoral and Assistant Prof. publications   29. S. Frølund, A. Bella, A. S. Kristensen, H. L. Ziegler, M. Witt, C. A. Olsen, K. Strømgaard, H. Franzyk, J. W. Jaroszewski. Assessment of Structurally Diverse Philanthotoxin Analogues for Inhibitory Activity on AMPA and NMDA Ionotropic Glutamate Receptor Subtypes: Discovery of Nanomolar, Non-Selective, and Use-Dependent Antagonists. J. Med. Chem. 2010, 53, 7441–7451.   28. C. A. Olsen,* H. L. Ziegler, H. M. Nielsen, N. Frimodt-Møller, J. W. Jaroszewski, H. Franzyk. Antimicrobial, Hemolytic, and Cytotoxic Activities of b-Peptoid–Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs. ChemBioChem. 2010, 11, 1356–1360.   27. C. A. Olsen.* Peptoid–Peptide Hybrid Backbone Architectures. ChemBioChem 2010, 11, 152–160. (This review article was selected for the Inside Cover graphics and was highlighted in the Spotlight section of Angewandte Chemie Int. Ed. 2010, 49, 836).   26. C. A. Olsen, M. R. Ghadiri. Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic alpha/beta-Tetrapeptides. J. Med. Chem. 2009, 52, 7836–7846.   25. W. S. Horne,† C. A. Olsen,† J. M. Beierle, A. Montero, M. R. Ghadiri. Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor Using Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides. Angew. Chem. Int. Ed. 2009, 48, 4718–4724. (†co-first author, this paper is highlighted in Nat. Chem. Biol. 2009, 5, 280)   24. A. Montero, J. M. Beierle, C. A. Olsen, M. R. Ghadiri. Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic alpha/beta-Tetrapeptide Architectures. J. Am. Chem. Soc. 2009, 131, 3033–3041.   23. L. K. Ottesen, C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Selectively N-Protected Enantiopure 2,5-Disubstituted Piperazines: Avoiding the Pitfalls in Solid-Phase Fukuyama-Mitsunobu Cyclizations. Chem.–Eur. J. 2009, 15, 2966–2978.   22. C. Foged, H. Franzyk, S. Bahrami, S. Frokjaer, J. W. Jaroszewski, H. M. Nielsen, C. A. Olsen. Cellular Uptake and Membrane-Destabilizing Properties of alpha-Peptide/beta-Peptoid Chimeras: Lessons for the Design of New Cell-Penetrating Peptides. Biochim. Biophys. Acta 2008, 1778, 2487–2495.   21. G. Bonke, L. Vedel, M. Witt, J. W. Jaroszewski, C. A. Olsen,* H. Franzyk.* Dimeric Building Blocks for Solid-Phase Synthesis of alpha-Peptide–beta-Peptoid Chimeras. Synthesis 2008, 2381–2390.   20. C. A. Olsen,* M. Lambert, M. Witt, H. Franzyk, J. W. Jaroszewski.. Solid-Phase Peptide Synthesis and Circular Dichroism Study of Chiral beta-Peptoid Homooligomers. Amino Acids 2008, 34, 465–471.   19. L. Vedel, G. Bonke, C. Foged, H. Ziegler, H. Franzyk, J. W. Jaroszewski, C. A. Olsen.* Antiplasmodial and Prehemolytic Activities of alpha-Peptide–beta-Peptoid Chimeras. ChemBioChem 2007, 8, 1781–1784.   18. C. A. Olsen,* G. Bonke, L. Vedel, A. Adsersen, M. Witt, H. Franzyk, J. W. Jaroszewski. alpha-Peptide/beta-Peptoid Chimeras. Org. Lett. 2007, 9, 1549–1552.     Graduate studies and follow-up publications   17. C. A. Olsen,* H. Franzyk, J. W. Jaroszewski. Aziridines in Parallel- and Solid-Phase Synthesis. Eur. J. Org. Chem. 2007, 1717–1724. (Review)   16. C. A. Olsen,* M. Witt, H. Franzyk, J. W. Jaroszewski. Solid-Phase Synthesis of Neuroactive Spider-Wasp Hybrid Toxin Analogues using a Backbone Amide Linker. Tetrahedron Lett. 2007, 48, 405–408.   15. C. A. Olsen,* C. Christensen, B. Nielsen, F. M. Mohamed, M. Witt, R. P. Clausen, J. L. Kristensen, J. W. Jaroszewski, H. Franzyk. Aminolysis of Resin-Bound N-Nosylaziridine-2-carboxylic Acids. Org. Lett, 2006, 8, 3371–3374.   14. K. Strømgaard, L. Piazzi, C. A. Olsen, H. Franzyk, J. W. Jaroszewski. Protolytic Properties of Polyamine Wasp Toxin Analogues Studied by 13C NMR Spectroscopy. Magn. Res. Chem. 2006, 44, 1013–1022.   13. D. Pla, A. Marchal, C. A. Olsen, A. Francesch, C. Cuevas, F. Albericio, M. Álvarez. Synthesis and Structure–Activity Relationship Study of Potent Cytotoxic Analogues of the Marine Alkaloid Lamellarin D. J. Med. Chem. 2006, 49, 3257–3268.   12. C. A. Olsen, I. R Mellor, P. Wellendorph, P. N. R. Usherwood, M. Witt, H. Franzyk, J. W. Jaroszewski. Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers. ChemMedChem 2006, 1, 303–305. (March issue Cover graphics).   11. C. A. Olsen, M. Witt, S. H. Hansen, J. W. Jaroszewski, H. Franzyk. Fukuyama-Mitsunobu Alkylation in Amine Synthesis on Solid Phase Revisited: N-Alkylation with Secondary Alcohols and Synthesis of Curtatoxins. Tetrahedron 2005, 61, 6046–6055.   10. C. A. Olsen, M. R. Jørgensen, S. H. Hansen, M. Witt, J. W. Jaroszewski, H. Franzyk. Side-Chain Anchored N-Fmoc-Tyr-OPfp for Bidirectional Solid-Phase Synthesis. Org. Lett, 2005, 7, 1707–1721.   9. M. R. Jørgensen, C. A. Olsen, I. R Mellor, P. N. R. Usherwood, M. Witt, J. W. Jaroszewski, H. Franzyk. Philanthotoxin Analogues: The Effect of Conformational Constraints and Steric Bulk in the Amino Acid Moiety of Philanthotoxins on AMPAR Antagonism. J. Med. Chem. 2005, 48, 56–70.   8. D. Pla, A. Marchal, C. A. Olsen, F. Albericio, M. Álvarez. Modular Total Synthesis of Lamellarin D. J. Org. Chem. 2005, 70, 8231–8234.   7. C. A. Olsen, N. Parera, F. Albericio, M. Álvarez. 5,6-Dihydropyrrolo[2,1-b]isoquinolines as Scaffolds for Synthesis of Lamellarin Analogues. Tetrahedron Lett. 2005, 46, 2041–2044.   6. C. A. Olsen, H. Franzyk, J. W. Jaroszewski. N-Alkylation and Indirect Formation of Amino Functionalities in Solid-Phase Synthesis. Synthesis 2005, 2631–2653. (Review)   5. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Expedient Protocol for Solid-Phase Synthesis of Secondary and Tertiary Amines. Org. Lett, 2004, 6, 1935–1938.   4. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Solid-Phase Synthesis of Acylpolyamines using Temporary N-4,4'-Dimethoxytrityl Protection in the Presence of Trityl Linkers. J. Org. Chem. 2004, 69, 6149–6152.   3. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Diols as Building Blocks in Solid-Phase Synthesis of Polyamine Toxins by Fukuyama-Mitsunobu Alkylation. Synlett 2004, 473–476.   2. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Solid-phase Polyamine Synthesis using Piperazine and Piperidine Building Blocks. Org. Lett. 2003, 5, 4183–4185.   1. C. A. Olsen, M. R. Jørgensen, M. Witt, I. R. Mellor, P. N. R. Usherwood, J. W. Jaroszewski, H. Franzyk. The Choice of Phosphane Reagent in Fukuyama-Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetramine Building Blocks for Synthesis of Philanthotoxins Eur. J. Org. Chem. 2003, 3288–3299.     (Other contributions)   Participation with a lecture in the DR2 TV program ”Danskernes Akademi” (Fall 2011).   Article in DTU-Avisen about my Lundbeck Junior Group Leader project (December 2010).   Participated in an interview regarding my Lundbeck Junior Group Leader Fellowship project in the TV2 talk show Lounge (Fall 2010).   An interview regarding my post doc project at TSRI was published in the annual report of the Danish Research Council for Technology and Production Sciences (Fall 2008).   C. A. Olsen, Interessante egenskaber ved nye peptid mimiks indeholdende unaturlige b-peptoid enheder. Dansk Kemi 2008, 89(2), 33-35.   C. A. Olsen, H. Franzyk, J. W. Jaroszewski, Kunstige forsvarspeptider–en ny måde at dræbe bakterier på. Lægemiddelforskning (DFU) 2006, 19-20.   C. A. Olsen, H. Franzyk, J. W. Jaroszewski, Nanomolær Inhibering med Hvepsetoksinanaloger – Syntese og Elektrofysiologi. Dansk Kemi 2006, 87(6/7), 23-26.

Collaborations