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Curriculum vitae  Name	Charlotte Held Gotfredsen
Title	Associate Professor
Date of birth	March 16, 1967
Affilation:	Department of Chemistry, Technical University of Denmark
Address:	Building 201, Kemitorvet, DK-2800 Kgs. Lyngby
Home Address:	Harrestrupvang 4, 1th, DK-2500 Valby
Phone:	+45 45252148
Fax	+45 45933968
Email:	chg@kemi.dtu.dk

 

Examina 

1995	Cand. Scient. - Chemistry and Cell-Biology, Odense University, SDU, Odense, Denmark
1998	Ph.D. - Chemistry, Odense University, SDU, Odense, Denmark

  

Honors

1999-2001 Personal research fellowship (talent projekt) from the Danish Technical Research Council.

 

Professional Experience

 

1994 - 1998	Modified oligonucleotide chemistry and NMR spectroscopy, Odense University. Advisor: Associate Prof. Jens Peter Jacobsen and Prof. Jesper Wengel.
1995 - 1996	NMR studies of triplex DNA/RNA, University of California, Los Angeles, California, USA. Advisor Prof. Juli Feigon.
1998 - 2004	Postdoc. Carlsberg Laboratory, Valby, Denmark. Advisor: Jens Ø. Duus.
2004 -	Associate Professor, Technical University of Denmark.

 

Teaching Experience

1992 / 1994	Laboratory assistant, Inorganic Chemistry at SDU.
1992 - 1994	Teaching assistant, Analytical Spectroscopy at SDU.
1996	Teaching assistent - Molecular Spectroscopy at SDU.
1997	Teaching assistent - Biomolecular Spectroscopy at SDU.
2004 -	Lecturer - Spectroscopy of Organic Compounds at DTU.
2004 -	Lecturer - Advanced NMR Spectroscopy at DTU.

 

 

 

Publications in international, refereed journals

"Chemotaxonomy of Veroniceae and its allies in the Plantaginaceae "
19. R.M. Taskova, C.H. Gotfredsen, S.R. Jensen, Phytochemistry 2006, 67, 286-301.

 

"Chemotaxonomic markers in Digitalideae (Plantaginaceae) "
19. R.M. Taskova, C.H. Gotfredsen, S.R. Jensen, Phytochemistry 2005, 66, 1440-1447.

 

"Inclusions of flavonoid 3-deoxyanthocyanidins in Sorghum bicolor self-organize into spherical structure "
K.A. Nielsen, C.H. Gotfredsen, M.J. Buch-Pedersen, H. Ammitzbøll, O. Mattsson, J. Ø. Duus, R.L. Nicholson, Physiological and Molecular Plant Pathology 2004, 65, 187-196.

 

"Iridoid glucosides of Paederota lutea and the relationships between Paederota and Veronica "
Dirk C. Albacha, Charlotte Held Gotfredsenb and Søren Rosendal Jensen, Phytochemistry 2004, 14, 2129-2134.

 

"SPOCC-194, a New High Functional Group Density PEG-Based Resin for Solid-Phase Organic Synthesis"
Les P. Miranda, William D. Lubell, Koen M. Halkes, Thomas Groth, Morten Grøtli, Jörg Rademann, Charlotte H. Gotfredsen, Morten Meldal, J. Comb. Chem. 2002, 4, 523-529.

 

"Epitope Diversity of N-glycans From Bovine Peripheral Myelin Glycoprotein P0 Revealed by Mass Spectrometry and Nano Probe Magic Angle Spinning 1H NMR Spectroscopy"
R.G. Gallego, J.L. Jiménez Blanco, C.W.E.M. Thijssen-van Zuylen, C.H. Gotfredsen, H. Voshol, J.Ø. Duus, M. Schachner, J.F.G. Vliegenthart, J. Biol. Chem. 2001, 276, 30834-30844.

 

" Solid-Phase Glycosylation of Peptide Templates and On-Bead MAS-NMR Analysis. Perspectives for Glycopeptide Libraries "
Koen M. Halkes, Charlotte H. Gotfredsen, Morten Grøtli, Les P. Miranda, Jens Ø. Duus, Morten Meldal, Chem. Eur. J. 2001, 7, 3584-3591.

 

" : Comparison of Aqueous Molecular Dynamics with NMR Relaxation and Residual Dipolar Couplings Favors Internal Motion in a Mannose Oligosaccharide."
Andy Almond, Jakob Bunkenborg, Thomas Franch, Charlotte H. Gotfredsen, Jens Ø. Duus, J. Am. Chem. Soc. 2001, 123, 4792-4802.

 

"Carbohydrate Structural Determination by NMR Spectroscopy: Modern Methods and Limitations "
Jens Ø. Duus, Charlotte H. Gotfredsen, and Klaus Bock, Chem. Rev. 2000, 100, 4589-4614.

 

" Synthesis and Application of Sialic Acid-containing Building Blocks for Glycopeptide Libraries. Establishing Glycosylation Conditions"
Koen M. Halkes, Phaedria M. St. Hilaire, Anita M. Jansson, Charlotte H. Gotfredsen, and Morten Meldal, J. Chem. Soc., Perkin Trans. 1 2000, 2127-2133.

 

" New Methods for Measuring 1H-31P Coupling Constants in Nucleic Acids" Charlotte H. Gotfredsen, Axel Meissner, Jens Ø. Duus, and Ole W. Sørensen, Magn. Reson. Chem. 2000, 38, 692-695.

 

" Single-bead Structure Elucidation. Requirements for Analysis of Combinatorial Solid-Phase Libraries by Nanoprobe MAS-NMR Spectroscopy"

Charlotte H. Gotfredsen, Morten Grøtli, Marianne Willert, Morten Meldal, and Jens Ø. Duus, J. Chem. Soc., Perkin Trans. 1 2000, 1167-1171.

 

" Physical Properties of Poly(ethylene glycol) (PEG)-Based Resins for Combinatorial Solid Phase Organic Chemistry: A Comparison of PEG-Cross-Linked and PEG-Grafted Resins"

Morten Grøtli, Charlotte H. Gotfredsen, Jörg Rademann, Jens Buchardt, Anthony J. Clark, Jens Ø. Duus, and Morten Meldal, J. Comb. Chem. 2000, 2, 108-119.

 

" NMR Structure of a DNA Duplex Containing the Modified Nucleotide 3’-C-(hydroxymethyl)thymidine"

Charlotte H. Gotfredsen, G. Viswanadham, Pia N. Jørgensen, Jesper Wengel, and Jens Peter Jacobsen., Asian Chem. Lett. 2000, 4, 171-184.

 

" Solution Structure of an Intramolecular Pyrimidine-Purine-Pyrimidine Triplex Containing an RNA Third Strand"
Charlotte H. Gotfredsen, Peter Schultze, and Juli Feigon., J. Am. Chem. Soc. 1998, 120, 4281-4289.

 

"Bis-Intercalation of Homodimeric Thiazole Orange Dyes in Selective Binding Sites of DNA Studied by 1H NMR Spectroscopy"
Lisbeth K. Jensen, Charlotte H. Gotfredsen, Kent Bondensgaard, and Jens Peter Jacobsen., Acta Chem. Scand. 1998, 52, 641-650.

 

" Structure of a DNA Duplex Containing a Single 2’-O-Methyl-β-D-araT: Combined Use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement "
Charlotte H. Gotfredsen, H. Peter Spielmann, Jesper Wengel, and Jens Peter Jacobsen, Bioconj. Chem. 1996, 7, 680-688.

 

"Synthesis and Properties of α- and β-Oligodeoxynucleotides Containing α- and β-1-(2-O-Methyl-D-arabinofuranosyl)thymine "
Charlotte H. Gotfredsen, Jens Peter Jacobsen, and Jesper Wengel, Bioorg. Med. Chem. 1996, 4, 1217-1225.

 

"Novel Oligodeoxy-nucleotide Analogues Containing A 2’-O-Methylarabinonucleoside "
Charlotte H. Gotfredsen, Jens Peter Jacobsen, and Jesper Wengel, Tetrahedron Lett. 1994, 35, 6941-6944.

 

 

Other publications

" Nano-Probe NMR in Structure Analysis" Charlotte Held Gotfredsen, Carbohydrates in Europe 1999, 24, 17.

 

"Synthesis and NMR Studies of Modified Oligonucleotides and Triple Stranded Structures; Charlotte H. Gotfredsen, Ph.D. Thesis, Odense University, 1998.